BMAL1, um gene de relógio, pode ser considerado como um marcador de prognóstico em pacientes acometidos por melanoma metastático e atua como um possível discriminador de pacientes que respondem ao tratamento com imunoterapia.
de Assis LVM, Kinker G, Moraes MN, Markus RP, Fernandes PA, Castrucci AML. 2018. Expression of the circadian clock gene BMAL1 positively correlates with antitumor immunity and patient survival in metastatic melanoma. Front Oncol, 8: 185.
https://www.frontiersin.org/articles/10.3389/fonc.2018.00185/full
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